
U.S. Highway 65 - Louisiana
U.S. 65 travels 101 miles in Louisiana between the Arkansas state line and U.S. 425 in Clayton. The routing originally continued all the way to New Orleans, but truncation occurred first in 1951 to Natchez and again in 2005 to Clayton. U.S. 425 saw extension from Bastrop to Rayville, Winnsboro, Clayton, Ferriday, Vidalia, and Natchez in 2005, replacing U.S. 65 in the process.

| U.S. Highway 65 north |
| The first northbound reassurance marker for U.S. 65 as the highway leaves junction U.S. 425 in the town of Clayton. Photo taken 06/12/04. |
| Louisiana 900 intersects U.S. 65 just east of U.S. 425 from the southeast. The state highway heads 4.3 miles south to junction Louisiana 568 at Lake Concordia. Photo taken 06/12/04. |
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| U.S. 65 travels a fairly straight line between Clayton and Azucena. St. Joseph, the Tensas Parish seat, is the next significant town of interest along the corridor, though it requires a turn onto Louisiana 128 east from U.S. 65. Photos taken 06/12/04. |
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